Best Agno Alternatives in 2026

OpenAI's official open-source framework for multi-agent workflows. Launched March 2025 as the production successor to Swarm. Provides handoffs, guardrails, tracing, and voice agent support in Python and TypeScript.

smolagents is Hugging Face's open-source Python library for building AI agents that write code as actions rather than JSON tool calls. Apache 2.0, ~1,000 lines of core code, supports 100-plus LLMs including local models via Ollama and Transformers.

PydanticAI is an open-source Python framework for building production-grade AI agents. Created by Samuel Colvin (creator of Pydantic), it brings FastAPI-style type safety, structured outputs, and dependency injection to agent development. Free, MIT-licensed, 16k+ GitHub stars.

Genkit is Google's open-source AI framework for TypeScript, Go, and Python developers. It provides typed flows, RAG, tool calling, and multi-agent support with a standout local Developer UI for iterating prompts and debugging traces. Free under Apache 2.0.

Mastra is an open-source TypeScript framework for building production AI agents, from the team behind Gatsby. It ships agents, durable workflows, RAG, built-in memory with SOTA LongMemEval scores, and a visual debugging studio.

Letta is the open-source agent framework from UC Berkeley's MemGPT research team. It gives AI agents persistent, self-editable memory using an OS-inspired three-tier architecture. Apache 2.0 with a cloud-hosted API option.

Haystack is deepset's open-source Python framework for building production-ready RAG pipelines and AI agents. Apache 2.0 licensed, it gives developers explicit control over retrieval, context routing, and generation through composable, YAML-serializable pipeline graphs.

Quivr is an open-source Python library for adding retrieval-augmented generation to any application. Apache 2.0, self-hostable, supports OpenAI, Anthropic, Mistral, and Groq. Built by a YC W24 team, with 39,000+ GitHub stars since its 2023 launch.

Dify is an Apache 2.0 open-source platform for building production-ready LLM applications. Visual workflow canvas, RAG pipelines, agent builder, and 100+ model integrations. Free self-hosted or $59/mo on cloud.

OpenHands is an open-source autonomous AI coding agent by All Hands AI. It plans, writes, executes, and debugs code inside a sandboxed environment without requiring manual approval at every step. Free to self-host; cloud tier available.